The heartfelt prayer of the righteous availeth much says the Apostle James. There is a powerful truth in the Bible about the heart. Proverbs says that one should guard his heart above all else , because out of it flows the issues of life. Thus one could safely assume that probably all the issues you are facing right now could be changed if you change your heart . Maybe your heart is filled with unforgiveness and resentment towards a person or a body of people . That very thing could be the reason it seems as if nothing seems to work for you. God cannot answer your prayers if there is unforgiveness in your heart . Unforgiveness will keep you out if heaven and drag you with a rope of bitterness to hell. Forgive as Christ has forgiven you.